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- J Lautermann, M Adamczyk, W J ten Cate, and O Kloke.
- Universitäts-Hals-Nasen-Ohrenklinik Essen.
- Laryngorhinootologie. 1998 Feb 1; 77 (2): 82-4.
BackgroundCarboplatin is regarded as a non-ototoxic or low-grade ototoxic chemotherapeutic agent.MethodWe report on three patients with a recurrence of testicular cancer after cisplatin chemotherapy who suffered hearing loss after subsequent high-dose carboplatin therapy.ResultsAudiometry demonstrated carboplatin-induced hearing loss primarily in the mid-range and high frequencies up to 45 dB at 3 kHz and up to 55 dB at 8 kHz. In two of three patients, transitory-evoked otoacoustic emissions were absent after carboplatin therapy.ConclusionFollowing first-line cisplatin chemotherapy, salvage treatment with high-dose carboplatin can generate hearing loss in the middle and high frequencies.
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