• Gan To Kagaku Ryoho · Jan 1984

    [Phase II study of 4'-O-tetrahydropyranyladriamycin(THP-ADM)].

    • H Nakada, M Ogawa, H Miyamoto, J Inagaki, N Horikoshi, K Inoue, K Ikeda, N Usui, K Adachi, and Y Okada.
    • Gan To Kagaku Ryoho. 1984 Jan 1; 11 (1): 138-42.

    AbstractA phase II clinical trial of a new anthracycline, 4'-O-tetrahydropyranyladriamycin (THP-ADM), was performed in thirty-one patients with advanced malignant tumors refractory to standard chemotherapies. The dosage of THP-ADM was 40 mg/m2 by iv bolus injection repeated every 3 weeks. Of 3 evaluable patients with non-Hodgkin's lymphoma, one achieved partial remission. A minor response was noted in one out of 7 patients with gastric cancer and one out of 5 patients with ovarian cancer. Leukopenia less than 4 X 10(3)/cmm and thrombocytopenia less than 100 X 10(3)/cmm were seen in 81% and 19% of cases, respectively. Mild gastrointestinal toxicities including nausea and vomiting and anorexia were observed in about one third of the patients. Mild hair loss occurred in 2 patients (6%). No ECG abnormalities on clinical sign of cardiotoxicity were seen.

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