• Am. J. Surg. · Sep 2015

    Comparative Study

    Hyperthermic intraperitoneal chemotherapy + early postoperative intraperitoneal chemotherapy versus hyperthermic intraperitoneal chemotherapy alone: assessment of survival outcomes for colorectal and high-grade appendiceal peritoneal carcinomatosis.

    • Jennifer Y Lam, Yarrow J McConnell, Justin D Rivard, Walley J Temple, and Lloyd A Mack.
    • Department of Surgery and Oncology, University of Calgary, Room 1006 & 1023, North Tower, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada. Electronic address: Jennifer.yk.lam@albertahealthservices.ca.
    • Am. J. Surg. 2015 Sep 1; 210 (3): 424-30.

    BackgroundCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have improved survival for colorectal and high-grade appendiceal carcinomatosis. We compared the overall and recurrence-free survival (OS and RFS) of patients treated with HIPEC with mitomycin c and early postoperative intraperitoneal chemotherapy (EPIC) with fluorouracil versus HIPEC alone using oxaliplatin and simultaneous IV infusion of fluorouracil.MethodsNinety-three patients with colorectal or high-grade appendiceal carcinomatosis were treated with CRS and HIPEC + EPIC or HIPEC alone. OS and RFS were analyzed using Kaplan-Meier curves and log-rank testing.ResultsSurvival did not differ between HIPEC regimens. The 3-year OS and RFS rates were 50% and 21% for HIPEC + EPIC and 46% and 6% for HIPEC alone (P = .72 and P = .89, respectively). HIPEC + EPIC patients experienced more grade III/IV complications (43.2% vs 19.6%, P = .01).ConclusionsThere was no difference in OS and RFS between colorectal and high-grade appendiceal adenocarcinoma patients treated with CRS and HIPEC + EPIC versus HIPEC alone. However, HIPEC + EPIC patients suffered greater morbidity, making HIPEC alone the preferable regimen.Copyright © 2015 Elsevier Inc. All rights reserved.

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