• Yuliang Wang, Jijie Xing, Ying Li, and Rui Zhang.
• Department of Rehabilitation, Beijing Xiaotangshan Hospital, Beijing, China.
• Medicine (Baltimore). 2021 Jul 16; 100 (28): e26636e26636.

BackgroundAs far as we know, no evidence has been established to assess the effects of acupuncture for acute cerebral infarction patients. Therefore, this systematic review and meta-analysis will be conducted to assess the efficacy and safety of acupuncture on cerebrovascular reserve in patients with acute cerebral infarction.MethodsOn June 20, 2021, the authors will perform a preliminary search in the PubMed, Embase, and Scopus databases using the following keywords: "acupuncture," "acute cerebral infarction." We will also examine the Clinical Trials Registry for other ongoing and unpublished studies. The inclusion criteria included (1) patients with acute cerebral infarction, (2) patients who received acupuncture, and (3) studies assessed cerebrovascular reserve, breath-holding index, Barthel index, and adverse events. All English language randomized controlled trials published within the last 20 years were eligible for inclusion. Primary outcome measures in our study are cerebrovascular reserve, and secondary outcome measures include the breath-holding index, Barthel index, and adverse events. All outcomes are pooled on a random-effect model.ResultsThe results of this research will be delivered in a peer-reviewed journal.Osf Registration Number10.17605/OSF.IO/7M4BK.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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