• Plos One · Jan 2015

    Comparative Study

    Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages.

    • Frederic Blanc, Sean J Colloby, Nathalie Philippi, Xavier de Pétigny, Barbara Jung, Catherine Demuynck, Clélie Phillipps, Pierre Anthony, Alan Thomas, Fabrice Bing, Julien Lamy, Catherine Martin-Hunyadi, John T O'Brien, Benjamin Cretin, Ian McKeith, Jean-Paul Armspach, and John-Paul Taylor.
    • University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
    • Plos One. 2015 Jan 1; 10 (6): e0127396.

    ObjectivesTo assess and compare cortical thickness (CTh) of patients with prodromal Dementia with Lewy bodies (pro-DLB), prodromal Alzheimer's disease (pro-AD), DLB dementia (DLB-d), AD dementia (AD-d) and normal ageing.MethodsStudy participants(28 pro-DLB, 27 pro-AD, 31 DLB-d, 54 AD-d and 33 elderly controls) underwent 3Tesla T1 3D MRI and detailed clinical and cognitive assessments. We used FreeSurfer analysis package to measure CTh and investigate patterns of cortical thinning across groups.ResultsComparison of CTh between pro-DLB and pro-AD (p<0.05, FDR corrected) showed more right anterior insula thinning in pro-DLB, and more bilateral parietal lobe and left parahippocampal gyri thinning in pro-AD. Comparison of prodromal patients to healthy elderly controls showed the involvement of the same regions. In DLB-d (p<0.05, FDR corrected) cortical thinning was found predominantly in the right temporo-parietal junction, and insula, cingulate, orbitofrontal and lateral occipital cortices. In AD-d(p<0.05, FDR corrected),the most significant areas affected included the entorhinal cortices, parahippocampal gyri and parietal lobes. The comparison of AD-d and DLB-d demonstrated more CTh in AD-d in the left entorhinal cortex (p<0.05, FDR corrected).ConclusionCortical thickness is a sensitive measure for characterising patterns of grey matter atrophy in early stages of DLB distinct from AD. Right anterior insula involvement may be a key region at the prodromal stage of DLB and needs further investigation.

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