• Stem Cell Res Ther · Jul 2020

    Review

    Mesenchymal stem cells: current clinical progress in ARDS and COVID-19.

    • Kun Xiao, Fei Hou, Xiuyu Huang, Binbin Li, Zhi Rong Qian, and Lixin Xie.
    • Department of Pulmonary and Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
    • Stem Cell Res Ther. 2020 Jul 22; 11 (1): 305.

    AbstractAcute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restricted fluid input, and there is no suggested pharmacological treatment. Mesenchymal stromal cells (MSCs) have been reported to be promising treatments for lung diseases. MSCs have been shown to have a number of protective effects in some animal models of ARDS by releasing soluble, biologically active factors. In this review, we will focus on clinical progress in the use of MSCs as a cell therapy for ARDS, which may have clinical implications during the coronavirus disease 2019 (COVID-19) pandemic.

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