• Roman C Maron, Michael Weichenthal, Jochen S Utikal, Achim Hekler, Carola Berking, Axel Hauschild, Alexander H Enk, Sebastian Haferkamp, Joachim Klode, Dirk Schadendorf, Philipp Jansen, Tim Holland-Letz, Bastian Schilling, Christof von Kalle, Stefan Fröhling, Maria R Gaiser, Daniela Hartmann, Anja Gesierich, Katharina C Kähler, Ulrike Wehkamp, Ante Karoglan, Claudia Bär, Titus J Brinker, and Collabrators.
• National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany.
• Eur. J. Cancer. 2019 Sep 1; 119: 57-65.

BackgroundRecently, convolutional neural networks (CNNs) systematically outperformed dermatologists in distinguishing dermoscopic melanoma and nevi images. However, such a binary classification does not reflect the clinical reality of skin cancer screenings in which multiple diagnoses need to be taken into account.MethodsUsing 11,444 dermoscopic images, which covered dermatologic diagnoses comprising the majority of commonly pigmented skin lesions commonly faced in skin cancer screenings, a CNN was trained through novel deep learning techniques. A test set of 300 biopsy-verified images was used to compare the classifier's performance with that of 112 dermatologists from 13 German university hospitals. The primary end-point was the correct classification of the different lesions into benign and malignant. The secondary end-point was the correct classification of the images into one of the five diagnostic categories.FindingsSensitivity and specificity of dermatologists for the primary end-point were 74.4% (95% confidence interval [CI]: 67.0-81.8%) and 59.8% (95% CI: 49.8-69.8%), respectively. At equal sensitivity, the algorithm achieved a specificity of 91.3% (95% CI: 85.5-97.1%). For the secondary end-point, the mean sensitivity and specificity of the dermatologists were at 56.5% (95% CI: 42.8-70.2%) and 89.2% (95% CI: 85.0-93.3%), respectively. At equal sensitivity, the algorithm achieved a specificity of 98.8%. Two-sided McNemar tests revealed significance for the primary end-point (p < 0.001). For the secondary end-point, outperformance (p < 0.001) was achieved except for basal cell carcinoma (on-par performance).InterpretationOur findings show that automated classification of dermoscopic melanoma and nevi images is extendable to a multiclass classification problem, thus better reflecting clinical differential diagnoses, while still outperforming dermatologists at a significant level (p < 0.001).Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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