• Vaccine · Nov 2010

    Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case-control study.

    • Joan Puig-Barberà, Alberto Arnedo-Pena, Francisco Pardo-Serrano, María Dolores Tirado-Balaguer, Silvia Pérez-Vilar, Ester Silvestre-Silvestre, Consuelo Calvo-Mas, Lourdes Safont-Adsuara, Montserrat Ruiz-García, and Surveillance and Vaccine Evaluation Group during the autumn 2009 H1N1 pandemic wave in Castellón, Spain.
    • Health Promotion Unit, Centro de Salud Pública, Avda del Mar, 12, 12003 Castellón, Spain. jpuigb@terra.es
    • Vaccine. 2010 Nov 3; 28 (47): 7460-7.

    AbstractWe estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castellón, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.Copyright © 2010 Elsevier Ltd. All rights reserved.

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