• Cytokine Growth Factor Rev. · Apr 2021

    AntagomiRs: A novel therapeutic strategy for challenging COVID-19 cytokine storm.

    • Sebastiano Gangemi and Alessandro Tonacci.
    • School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Via Consolare Valeria SNC, 98125 Messina, Italy.
    • Cytokine Growth Factor Rev. 2021 Apr 1; 58: 111-113.

    AbstractIs it possible to develop a reliable, safe treatment for the widespread COVID-19 pandemic shortly? COVID-19 is characterized by a disruptive cytokine storm, quickly and often irreversibly damaging the patient's lungs, as its main target organ, leading to lung failure and death. Actual experimental therapies are trying to reduce the activation of some specific cytokines, such as IL-6, somewhat reducing the burden for the patient. However, they are often unable to block the whole storm occurring at the cytokine level. In presence of the cytokine storm, especially in severe patients, antagomiRs, already demonstrated to be efficient and secure in cardiovascular disease, could represent a useful alternative to such treatment, customizable upon the disease specificities and applicable to other coronaviruses possibly associated with such clinical manifestations, while a reliable, efficient vaccine is being distributed.Copyright © 2020 Elsevier Ltd. All rights reserved.

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