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- M B Miller and P J Koltai.
- Division of Otolaryngology, Albany (NY) Medical College, USA.
- Arch Otolaryngol. 1995 Jun 1; 121 (6): 678-80.
ObjectiveTo compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite.DesignThe frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline.Main Outcome MeasuresTissue survival was calculated as the percent of total frostbite area that remained after 2 weeks.ResultsThe control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%).ConclusionPentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.
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