• Gustavo G Protti, Rubens J Gagliardi, Wilma C N Forte, and Sandra Regina S Sprovieri.
• Emergency Service, Department of Medicine.
• Arq Neuropsiquiatr. 2013 Nov 1; 71 (11): 846-51.

UnlabelledAtherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury.Objectives1) To assess the relationship between stroke severity and the serum levels of IL-1β, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins.MethodWe measured the serum levels of IL-1β, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls.ResultsPatients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h.ConclusionIL-10 may protect against ischemic injury during the acute phase of stroke.

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