• Cancer investigation · Oct 2010

    Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: a phase II study.

    • Michele Orditura, Gennaro Galizia, Vincenzo Napolitano, Erika Martinelli, Roberto Pacelli, Eva Lieto, Gaetano Aurilio, Loredana Vecchione, Floriana Morgillo, Giuseppe Catalano, Fortunato Ciardiello, Alberto Del Genio, Natale Di Martino, and Ferdinando De Vita.
    • Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, Second University of Naples, School of Medicine, Naples, Italy.
    • Cancer Invest. 2010 Oct 1; 28 (8): 820-7.

    AbstractWe evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.

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