• Internal medicine · Feb 2022

    Case Reports

    Thymic Adenocarcinoma with Positivity for Thyroid Transcription Factor-1 and a BRAF V600E Mutation: A Case Report.

    • Takafumi Yorozuya, Mitsuo Otsuka, Shin Ichihara, Kento Fujimori, Chikako Kitamura, Tomoyuki Takahashi, Masaki Mori, Yasushi Cho, and Hirofumi Chiba.
    • Department of Respiratory Medicine, Sapporo Kosei General Hospital, Japan.
    • Intern. Med. 2022 Feb 1; 61 (3): 385-388.

    AbstractThymic adenocarcinomas are rare. We herein report for the first time a case of thymic adenocarcinoma with positivity for thyroid transcription factor-1 (TTF-1) and a BRAF V600E mutation. A 50-year-old woman had persistent suffocation and chest pain. Computed tomography revealed a 42×28-mm tumor in the anterior mediastinum. The patient underwent tumor resection using video-assisted thoracoscopic surgery. Histopathological findings showed thymic papillary adenocarcinoma, Masaoka stage II. Immunohistochemically, the tumor was positive for TTF-1. A sequencing analysis revealed a BRAF V600E mutation. The patient underwent postoperative radiotherapy and was in good health without recurrence at five months after resection.

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