• J T P Lansu, M Essers, A C Voogd, E J T Luiten, C Buijs, N Groenendaal, and P M H Poortmans.
• Institute Verbeeten, Radiation Oncology Department, Postbus 90120, 5000 LA Tilburg, The Netherlands; Maastricht University, Department of Epidemiology, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address: j.lansu@student.maastrichtuniversity.nl.
• Eur J Surg Oncol. 2015 Oct 1; 41 (10): 1411-6.

IntroductionWe retrospectively investigated the possible influence of a simultaneous integrated boost (SIB), hypofractionation and oncoplastic surgery on cosmetic outcome in 125 patients with stage I-II breast cancer treated with breast conserving therapy (BCT).Patients And MethodsThe boost was given sequentially (55%) or by SIB (45%); fractionation was conventional (83%) or hypofractionated (17%); the surgical technique was a conventional lumpectomy (74%) or an oncoplastic technique (26%). We compared cosmetic results subjectively using a questionnaire independently completed by the patient and by the physician and objectively with the BCCT.core software. Independent-samples T-tests were used to compare outcome in different groups. Patients also completed the EORTC QLQ C30 and BR23.ResultsUnivariate analyses indicated no significant differences of the cosmetic results (P ≤ 0.05) for the type of boost or fractionation. However, the conventional lumpectomy group scored significantly better than the oncoplastic group in the BCCT.core evaluation, without a significant difference in the subjective cosmetic evaluation. Quality of life outcome was in favour of SIB, hypofractionation and conventional surgery.ConclusionOur study indicates that the current RT techniques seem to be safe for cosmetic outcome and quality of life. Further investigation is needed to verify the possible negative influence of oncoplastic surgery on the cosmetic outcome and the quality of life as this technique is especially indicated for patients with an unfavourable tumour/breast volume ratio.Copyright © 2015 Elsevier Ltd. All rights reserved.

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