• Lakshmi Kallur, Alexei Gonzalez-Estrada, Frank Eidelman, and Ves Dimov.
• a Internal Medicine Resident, Department of Internal Medicine , East Tennessee State University , Johnson City , TN , USA.
• Expert Opin Drug Metab Toxicol. 2017 Dec 1; 13 (12): 1275-1280.

IntroductionMepolizumab is a humanized monoclonal antibody that binds to and inactivates IL-5. It is available as a subcutaneous preparation. The practical application of mepolizumab is as an add-on therapy in the treatment of severe eosinophilic asthma. Areas covered: This article was created from a comprehensive literature search with information taken from meta-analyses, systematic reviews, and clinical trials of adults. The articles that have been selected evaluate the use of mepolizumab and its role in eosinophilic asthma. Expert opinion: Mepolizumab is significantly more effective than placebo in reducing exacerbations and need for systemic corticosteroids in severe eosinophilic asthma. There is a lack of head to head studies comparing mepolizumab to other monoclonal anti-IL-5 inhibitors in severe eosinophilic asthma. Post marketing surveillance revealed risk of anaphylaxis that is below 1%.

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