• Vincenzo Ambrogi, Riccardo Tajè, and Tommaso Claudio Mineo.
• Department of Surgical Sciences, Tor Vergata University, Via Montpellier 1, Rome 00133, Italy; Division of Thoracic Surgery, Tor Vergata University Policlinic, Viale Oxford 81, Rome 00133, Italy. Electronic address: ambrogi@med.uniroma2.it.
• Thorac Surg Clin. 2020 Feb 1; 30 (1): 49-59.

AbstractWedge resection in peripheral lung cancer is considered a suboptimal procedure. However, in elderly and/or frail patients it is a reliable and safer alternative. This procedure can be easily performed under nonintubated anesthesia, allowing the recruitment of patients considered otherwise marginal for a surgical treatment. Nonintubated anesthesia can reduce lung trauma, operative time, postoperative morbidity, hospital stay, and global expenses. Furthermore, nonintubated anesthesia produces less immunologic impairment and this may affect postoperative oncological long-term results. Wedge lung resection through nonintubated anesthesia can be performed for diagnosis with higher effectiveness given the similar invasiveness of computed tomography-guided biopsy.Copyright © 2019 Elsevier Inc. All rights reserved.

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