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- Ecaterina Turtureanu-Hanganu.
- University Hospital Sf. Spiridon, Medical Clinic of Hematology, School of Medicine, University of Medicine and Pharmacy Gr.T. Popa, Iaşi.
- Rev Med Chir Soc Med Nat Iasi. 2002 Oct 1; 106 (4): 705-11.
AbstractThe Tumor Lysis Syndrome (TLS) is a constellation of metabolic disturbances due to the rapid tumoral cell destruction, either spontaneous or induced by cytoreduction therapy, which manifests as an acute, subacute or chronic renal insufficiency. Hyperuricemia is the hallmark of the TLS. The therapy consists in management of hydro-electrolytic and metabolic disturbances, treatment of hyperuricemia (Allopurinol and a new therapeutical agent, Uricase), hemodialysis. If promptly supported during the TLS, a number of these patients have an excellent probability of long-term remission.
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