• Anna Rosenberg, Tiia Ngandu, Minna Rusanen, Riitta Antikainen, Lars Bäckman, Satu Havulinna, Tuomo Hänninen, Tiina Laatikainen, Jenni Lehtisalo, Esko Levälahti, Jaana Lindström, Teemu Paajanen, Markku Peltonen, Hilkka Soininen, Anna Stigsdotter-Neely, Timo Strandberg, Jaakko Tuomilehto, Alina Solomon, and Miia Kivipelto.
• Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland. Electronic address: anna.rosenberg@uef.fi.
• Alzheimers Dement. 2018 Mar 1; 14 (3): 263-270.

IntroductionThe 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.MethodsThe FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.ResultsSociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05).ConclusionsThe FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

27 keywords...

hide…