• Fredrik Karlsson, Elin Malinova, Katarina Olofsson, Patric Blomstedt, Jan Linder, and Erik Nordh.
• Department of Clinical Sciences, Division of Speech and Language Pathology, Umeå University, Umeå, Sweden. Electronic address: fredrik.k.karlsson@umu.se.
• J Voice. 2019 Jul 1; 33 (4): 545-549.

ObjectivesWe aimed to study the effect of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and caudal zona incerta (cZi) on level of perceived voice tremor in patients with Parkinson disease (PD).Study DesignThis is a prospective nonrandomized design with consecutive patients.MethodsPerceived voice tremor was assessed in patients with PD having received either STN-DBS (8 patients, 5 bilateral and 3 unilateral, aged 43.1-73.6 years; median = 61.2 years) or cZi-DBS (14 bilateral patients, aged 39.0-71.9 years; median = 56.6 years) 12 months before the assessment. Sustained vowels that were produced OFF and ON stimulation (with simultaneous l-DOPA medication) were assessed perceptually in terms of voice tremor by two raters on a four-point rating scale. The assessments were repeated five times per sample and rated in a blinded and randomized procedure.ResultsThree out of the 22 patients (13%) were concluded to have voice tremor OFF stimulation. Patients with PD with STN-DBS showed mild levels of perceived voice tremor OFF stimulation and a group level improvement. Patients with moderate/severe perceived voice tremor and cZi-DBS showed marked improvements, but there was no overall group effect. Six patients with cZi-DBS showed small increases in perceived voice tremor severity.ConclusionsSTN-DBS decreased perceived voice tremor on a group level. cZi-DBS decreased perceived voice tremor in patients with PD with moderate to severe preoperative levels of the symptom.Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

29 keywords...

hide…