• M Luigetti, R Iorio, A R Bentivoglio, L Tricoli, V Riso, J Marotta, C Piano, G Primiano, L Zileri Del Verme, M R Lo Monaco, P Calabresi, and GEMELLI AGAINST COVID-19 group.
• Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
• Eur. J. Neurol. 2020 Nov 1; 27 (11): 2322-2328.

Background And PurposeThe objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2.MethodsPatients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group.ResultsIn all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection.ConclusionsPatients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.© 2020 European Academy of Neurology.

35 keywords...

hide…