• Jong-Lyel Roh, Jae Seung Kim, Byung Chul Kang, Kyung-Ja Cho, Sang-wook Lee, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, and Sang Yoon Kim.
• Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
• J Surg Oncol. 2014 Dec 1; 110 (7): 869-75.

BackgroundTo evaluate the usefulness of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by pretreatment fluorine 18-fluorodeoxyglucose ((18) F-FDG) positron emission tomography (PET)/computed tomography (CT) as predictors of clinical outcome in hypopharyngeal squamous cell carcinoma (HPSCC).MethodsSeventy-eight patients with HPSCC treated with definitive radiotherapy with or without chemotherapy underwent (18) F-FDG PET/CT. Maximum standardized uptake value (SUV max ), MTV, and TLG were measured. For calculation of MTV, 3-D regions of interest were drawn and a SUV threshold of 2.5 was used for defining region. Univariate and multivariate analyses identified variables associated with disease-free survival (DFS) and overall survival (OS).ResultsMedian SUV max , MTV, and TLG were 9.0 (range, 1.7-24.5), 20.5 (0.3-339.9) ml, and 98.9 (0.8-1877.1) g, respectively. The four-year DFS and OS were 56.1% and 52.6%, respectively. On univariate and multivariate analyses, MTV (P = 0.014) and TLG (P = 0.029) were independent prognostic factors for DFS, and MTV (P = 0.002) and TLG (P = 0.002) were independent prognostic factors for OS.ConclusionMTV and TLG measured by pretreatment (18) F-FDG PET/CT may be useful in predicting the clinical outcomes of HPSCC patients undergoing radiotherapy.© 2014 Wiley Periodicals, Inc.

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