• Neurobiology of disease · Mar 2019

    Review

    The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol.

    • Paul M Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J Bell, Thomas P Bleck, Manuel Buitrago Blanco, Jan Claassen, Ramon Diaz-Arrastia, Dominique Duncan, Ben Ellingson, Brandon Foreman, Emily J Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien, Kristine O'Phelan, Courtney L Robertson, Eric Rosenthal, Richard Staba, Arthur Toga, Frederick A Willyerd, Lara Zimmermann, Elisa Yam, Susana Martinez, Courtney Real, and Jerome Engel.
    • David Geffen School of Medicine at UCLA, United States. Electronic address: pvespa@mednet.ucla.edu.
    • Neurobiol. Dis. 2019 Mar 1; 123: 110-114.

    AbstractThe Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.Copyright © 2018 Elsevier Inc. All rights reserved.

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