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J. Thromb. Haemost. · Nov 2016
Comparative StudyRivaroxaban limits complement activation compared with warfarin in antiphospholipid syndrome patients with venous thromboembolism.
- D R J Arachchillage, I J Mackie, M Efthymiou, A Chitolie, B J Hunt, D A Isenberg, M Khamashta, S J Machin, and H Cohen.
- Department of Haematology, Haemostasis Research Unit, University College London, London, UK.
- J. Thromb. Haemost. 2016 Nov 1; 14 (11): 2177-2186.
AbstractEssentials Complement activation has a pathogenic role in thrombotic antiphospholipid syndrome (APS). Coagulation proteases such as factor Xa can activate complement proteins. Complement activation markers were elevated in anticoagulated thrombotic APS patients. Complement activation decreased in APS patients switching from warfarin to rivaroxaban.© 2016 International Society on Thrombosis and Haemostasis.
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