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Nature reviews. Cancer · Aug 2007
ReviewUnderstanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets.
- Teru Hideshima, Constantine Mitsiades, Giovanni Tonon, Paul G Richardson, and Kenneth C Anderson.
- Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
- Nat. Rev. Cancer. 2007 Aug 1; 7 (8): 585-98.
AbstractMultiple myeloma is a plasma cell malignancy characterized by complex heterogeneous cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies. Although multiple myeloma remains incurable, novel targeted agents, used alone or in combination, have shown great promise to overcome conventional drug resistance and improve patient outcome. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma, providing the framework for new prognostic classification and identifying new therapeutic targets.
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