• Xingfeng Shao, Yi Wang, Steen Moeller, and WangDanny J JDJJLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Soutern California, Los Angeles, California, USA..
• Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Soutern California, Los Angeles, California, USA.
• Magn Reson Med. 2018 Jan 1; 79 (1): 394-400.

PurposeTo present a constrained slice-dependent (CSD) background-suppression (BS) scheme in 2D arterial spin labeling (ASL) using simultaneous multislice acquisition with blipped-CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration).MethodsBackground suppression for 2D acquisition is challenging because of the multiple nulling points required for sequential slice readout. Constrained slice-dependent BS exploits the simultaneous multislice technique to reduce the readout duration, and uses slice-dependent premodulation pulses to achieve BS across slice groups. The proposed scheme was evaluated by in vivo brain experiments at 3 Tesla with multiband acceleration factors up to four. The utility of CSD BS was demonstrated through comparison against standard 2D acquisitions as well as 3D-BS pseudo-continuous ASL (pCASL).ResultsAn average of 95% background signal reduction was achieved with CSD BS. As a result, the temporal signal-to-noise ratio (SNR) increased 48.2/39.9/36.9/36.0% and spatial SNR increased 132.5/80.0/63.5/54.2 in CSD-BS MB-1/2/3/4 scans, respectively. Whole-brain coverage was achievable with CSD-BS pCASL with MB-4, which yielded comparable spatial SNR as 3D BS pCASL.ConclusionsThe proposed CSD-BS scheme for 2D-SMS pCASL offers a promising approach for effective suppression of background signals across a wide range of T1 to achieve whole-brain perfusion imaging. Magn Reson Med 79:394-400, 2018. © 2017 International Society for Magnetic Resonance in Medicine.© 2017 International Society for Magnetic Resonance in Medicine.

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