• Jake R Morgan, Bruce R Schackman, Zoe M Weinstein, Alexander Y Walley, and Benjamin P Linas.
• Department of Medicine, Section of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue Boston, MA, 02118, USA. Electronic address: jakem@bu.edu.
• Drug Alcohol Depend. 2019 Jul 1; 200: 34-39.

Background And AimsDespite the growing opioid overdose crisis, medication treatment for opioid use disorder remains uncommon. The comparative effectiveness of buprenorphine and naltrexone treatment in reducing overdose and the comparative risks of discontinuing treatment in the real world, remain uncertain. Our aim was to examine the effectiveness of medications for opioid use disorder in preventing opioid-related overdose.DesignRetrospective cohort study SETTING: United States.Patients46,846 commercially insured individuals diagnosed with opioid use disorder and initiating medication treatment between 2010 and 2016.MeasurementsOpioid-related overdose identified by International Classification of Diseases, Ninth and Tenth Revisions.FindingsIn our sample, 1386 individuals were prescribed extended-release injectable naltrexone (median filled prescriptions = 9 months), 7782 were prescribed oral naltrexone (5 months), and 40,441 were prescribed buprenorphine (19 months) at least once during follow-up. Individuals receiving buprenorphine therapy were at significantly reduced risk of opioid-related overdose compared to no treatment (adjusted hazard ratio (HR) = 0.40, 95% CI 0.35-0.46), while a significant association was not observed in extended-release injectable (HR = 0.74, 95% CI 0.42-1.31) or oral (HR = 0.93, 95% CI 0.71-1.22) naltrexone. We found no association with opioid overdose within four weeks of discontinuation of any medication.ConclusionAmong commercially-insured patients who initiate medications for opioid use disorder, buprenorphine, but not naltrexone, was associated with lower risk of overdose during active treatment compared to post-discontinuation. More research is needed to understand the benefits and risks unique to each treatment option to better tailor therapies to patients with opioid use disorder.Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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