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Clinics in chest medicine · Jun 2021
ReviewDiagnosis and Management of Fibrotic Interstitial Lung Diseases.
- Bridget F Collins and Fabrizio Luppi.
- Department of Medicine, Center for Interstitial Lung Diseases, University of Washington Medical Center, 1959 NE Pacific Street, Box 356166, Seattle, WA 98195-6166, USA. Electronic address: bfc3@uw.edu.
- Clin. Chest Med. 2021 Jun 1; 42 (2): 321-335.
AbstractNonidiopathic pulmonary fibrosis (non-IPF) progressive fibrotic interstitial lung diseases (PF-ILDs) are a heterogeneous group of ILDs, often challenging to diagnose, although an accurate diagnosis has significant implications for both treatment and prognosis. A subgroup of these patients experiences progressive deterioration in lung function, physical performance, and quality of life after conventional therapy. Risk factors for ILD progression include older age, lower baseline pulmonary function, and a usual interstitial pneumonia pattern. Management of non-IPF P-ILD is both pharmacologic and nonpharmacologic. Antifibrotic drugs, originally approved for IPF, have been considered in patients with other fibrotic ILD subtypes, with favorable results in clinical trials.Copyright © 2021 Elsevier Inc. All rights reserved.
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