• Kübra Eren Bozdağ, Seref Gülseren, Füsun Güven, and Birmay Cam.
• Department of Dermatology, Atatürk Training and Research Hospital, Izmir, Turkey. bozdagk@gmail.com
• J Dermatolog Treat. 2009 Jan 1; 20 (5): 293-6.

BackgroundThere have been concerns about the association between isotretinoin therapy and depressive symptoms.ObjectiveThe objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression.MethodsA total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment.ResultsWe detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up.ConclusionsOur results provide no relationship between isotretinoin use and depression in acne patients.

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