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Journal of chemotherapy · Jun 1993
Review Comparative StudyCisplatinum based chemotherapy: role of the antiserotoninergic ondansetron in prevention of emesis.
- M C Locatelli, A D'Antona, and G Luporini.
- Medical Oncology Department, S. Carlo Borromeo Hospital, Milan, Italy.
- J Chemother. 1993 Jun 1; 5 (3): 197-206.
AbstractSerotonin is a neurotransmitter involved in chemotherapy-induced emesis and ondansetron is a new drug endowed with selective antagonism against the 5HT3 receptors. Phase I-II studies have demonstrated its activity against acute emesis after single-dose cisplatin, reporting particularly low toxicity; in comparative studies with high-dose metoclopramide, it has been proved to be more effective and completely devoid of extrapyramidal side effects. Ondansetron has shown its activity and safety also in multiple-day cisplatin regimens. Its antiemetic efficacy is improved by the addition of dexamethasone. Preliminary data suggest its role also when used in single-dose administration. Its activity in the delayed phase of cisplatin emesis needs to be further explored.
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