• L Schwingshackl, G Rüschemeyer, and J J Meerpohl.
• Institut für Evidenz in der Medizin, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Breisacher Straße 86, 79110, Freiburg, Deutschland. schwingshackl@ifem.uni-freiburg.de.
• Urologe A. 2021 Apr 1; 60 (4): 444-454.

BackgroundGRADE (Grading of Recommendations, Assessment, Development and Evaluation) is a widely used approach in the fields of medicine and public health to assess the outcome-specific certainty of the evidence in systematic reviews.ObjectivesTo make the GRADE approach comprehensible in order to facilitate the reading, understanding and interpretation of GRADE assessments in systematic reviews.Materials And MethodsPresentation of the procedure of the GRADE approach using the example of a Cochrane review on selenium supplements in the prevention of prostate cancer.ResultsGRADE provides criteria for rating the certainty of evidence. GRADE's approach to rating the certainty of the evidence is based on a four-level system (high, moderate, low, very low). The GRADE approach classifies bodies of randomized controlled trials as initially starting at high certainty and bodies of observational studies at initially starting at low certainty. By assessing the five domains (risk for bias, inconsistency, indirectness, insufficient precision and publication bias), certainty can be rated down or, in the case of large effects, existing dose-response relationships or plausible confounders, rated up.ConclusionsGRADE is a consistent and transparent approach for rating the certainty of a body of evidence by offering explicit key questions.

9 keywords...

hide…