• Indian J Dermatol Venereol Leprol · Nov 2009

    Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.

    • Timir Y Mehta, Laxman M Prajapati, Bharti Mittal, Chaitanya G Joshi, Jayesh J Sheth, Dinesh B Patel, Dinkar M Dave, and Ramesh K Goyal.
    • Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India. samarpan_research@yahoo.co.in
    • Indian J Dermatol Venereol Leprol. 2009 Nov 1; 75 (6): 579-82.

    BackgroundStevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.AimTo study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.MethodsEight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.ResultsOut of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.ConclusionThis study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

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