• Clin Exp Obstet Gyn · Jan 1991

    Uterine motility and cervical ripening in second trimester elective abortion by two different PGE analogues.

    • A Di Lieto, D Catalano, G Albano, N Uccello, A Civetta, R Ferrara, R Fimiani, M Pontillo, and A Paladini.
    • II Medical School, Department of Gynecology and Obstetrics, University of Naples Federico II.
    • Clin Exp Obstet Gyn. 1991 Jan 1; 18 (4): 251-9.

    AbstractThe clinical effects were studied of two different PGE analogues on the uterine motility and cervical ripening of eighty pregnant women asking for a second trimester elective abortion for fetal abnormalities. Forty women received vaginal suppositories each containing 1 milligram of 16, 16-dimethyl-trans-s2-PGE1 (Gemeprost) every 3 hours (5 mg max). Intramuscular injections of 500 micrograms of 16-phenoxy-w 17, 18, 19, 20 tetranor PGE2 methyl-sulphonylamide (Sulprostone) were administered every four hours (2000 mcg max.) to the remaining forty patients. Thirty-three Gemeprost treated patients (82.5%) and 34 Sulprostone treated patients (85%) experienced a complete abortion in the mean of 12.92 +/- 6.95 hours and 11.88 +/- 6.8 hours respectively. The histological and ultrastructural findings of cervical ripening were similar in both groups, while the tocographic patterns showed different characteristics. Side effects occurred in 16 Sulprostone (40%), but only in 9 (22.5%) Gemeprost treated patients, demonstrating that Gemeprost, although equally effective, is better tolerated.

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