• Yiwey Shieh, Laura Fejerman, Paul C Lott, Katie Marker, Sarah D Sawyer, Donglei Hu, Scott Huntsman, Javier Torres, Magdalena Echeverry, Mabel E Bohórquez, Juan Carlos Martínez-Chéquer, Guadalupe Polanco-Echeverry, Ana P Estrada-Flórez, COLUMBUS Consortium, Christopher A Haiman, Esther M John, Lawrence H Kushi, Gabriela Torres-Mejía, Tatianna Vidaurre, Jeffrey N Weitzel, Sandro Casavilca Zambrano, Luis G Carvajal-Carmona, Elad Ziv, and Susan L Neuhausen.
• Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA.
• J. Natl. Cancer Inst. 2020 Jun 1; 112 (6): 590-598.

BackgroundMore than 180 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified; these SNPs can be combined into polygenic risk scores (PRS) to predict breast cancer risk. Because most SNPs were identified in predominantly European populations, little is known about the performance of PRS in non-Europeans. We tested the performance of a 180-SNP PRS in Latinas, a large ethnic group with variable levels of Indigenous American, European, and African ancestry.MethodsWe conducted a pooled case-control analysis of US Latinas and Latin American women (4658 cases and 7622 controls). We constructed a 180-SNP PRS consisting of SNPs associated with breast cancer risk (P < 5 × 10-8). We evaluated the association between the PRS and breast cancer risk using multivariable logistic regression, and assessed discrimination using an area under the receiver operating characteristic curve. We also assessed PRS performance across quartiles of Indigenous American genetic ancestry. All statistical tests were two-sided.ResultsOf 180 SNPs tested, 142 showed directionally consistent associations compared with European populations, and 39 were nominally statistically significant (P < .05). The PRS was associated with breast cancer risk, with an odds ratio per SD increment of 1.58 (95% confidence interval [CI = 1.52 to 1.64) and an area under the receiver operating characteristic curve of 0.63 (95% CI = 0.62 to 0.64). The discrimination of the PRS was similar between the top and bottom quartiles of Indigenous American ancestry.ConclusionsThe 180-SNP PRS predicts breast cancer risk in Latinas, with similar performance as reported for Europeans. The performance of the PRS did not vary substantially according to Indigenous American ancestry.© The Author(s) 2019. Published by Oxford University Press.

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