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Clin Neuropharmacol · Jan 1993
ReviewSerotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation.
- P J Cowen.
- MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, England.
- Clin Neuropharmacol. 1993 Jan 1; 16 Suppl 3: S6-18.
AbstractSerotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT receptor ligands has allowed the assessment of specific 5-HT receptor subtype function using neuroendocrine methods. Studies with selective antagonists have shown that the endocrine responses to the 5-HT precursor L-tryptophan (LTP) are mediated via postsynaptic 5-HT1A receptors, whereas endocrine responses produced by the 5-HT-releasing agent d-fenfluramine involve postsynaptic 5-HT2/1C receptors. Endocrine responses to both LTP and fenfluramine are consistently decreased in depressive illness. In contrast, endocrine responses to direct 5-HT1A and 5-HT2/1C receptor agonists are not consistently attenuated in depressed patients. The current data suggest that depressive illness is associated with an impairment of 5-HT neurotransmission that involves decreased 5-HT release rather than altered sensitivity of postsynaptic 5-HT receptors.
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