• Hiroshi Kawaji, Takamichi Yamamoto, Ayataka Fujimoto, Daiki Uchida, Naoki Ichikawa, Tomohiro Yamazoe, Tohru Okanishi, Keishiro Sato, Mitsuyo Nishimura, Tokutaro Tanaka, and Hiroki Namba.
• Departments of Neurosurgery, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, 430-8558, Japan; Departments of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
• Neurosci. Lett. 2020 Jan 18; 716: 134636.

AbstractAspireSR is a novel vagus nerve stimulation (VNS) device which detects ictal heart rate changes and automatically apply additional stimulus. We investigated the difference of the efficacy between AspireSR and preceding VNS models in patients with device replacement. We retrospectively reviewed the clinical data of 17 patients whose VNS devices were changed because of battery discharge. The rates of seizure reduction, the number of antiepileptic drugs (AEDs) used and device parameters between the two devices were evaluated. AspireSR improved significantly the rates of seizure reduction of the patients. Four patients out of 11 patients with low response to the preceding VNS models (no change or <50 % reduction) achieved>50 % seizure reduction. The AEDs used were not different in the observed periods. The device parameters were low setting in AspireSR compared to preceding VNS models. AspireSR decrease significantly seizure frequencies compared to the preceding VNS models. Change of the devices to AspireSR at the time of battery empty could be recommendable.Copyright © 2019 Elsevier B.V. All rights reserved.

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