• Surgical oncology · Sep 2013

    Review

    Meta-analysis: accuracy of 18FDG PET-CT for distant metastasis staging in lung cancer patients.

    • Junkai Li, Wen Xu, Fanjun Kong, Xueling Sun, and Xiaoyan Zuo.
    • Department of Oncology, The No. 456 Hospital of People's Liberation Army, Jinan 250031, PR China.
    • Surg Oncol. 2013 Sep 1; 22 (3): 151-5.

    BackgroundWe undertook a meta-analysis to evaluate the accuracy of (18)FDG PET-CT for diagnosis of distant metastases in lung cancer patients.MethodsStudies about (18)FDG PET-CT for diagnosis of distant metastases in patients with lung cancer were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, positive likelihood ratios and negative likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT.ResultsAcross 9 studies (780 patients), the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of (18)FDG PET-CT were 0.93 (95% confidence interval [CI] = 0.88-0.96), 0.96 (95% CI = 0.95-0.96), 28.4 (95% CI = 14.0-57.5), and 0.08 (95% CI = 0.02-0.37), respectively. Overall weighted area under the curve was 0.98 (95% CI = 0.96-0.99).Conclusion(18)FDG PET-CT has excellent diagnostic performance for diagnosis of distant metastases in patients with lung cancer.Copyright © 2013 Elsevier Ltd. All rights reserved.

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