• Yihang Zhou, Prachi Pandit, Valentina Pedoia, Julien Rivoire, Yanhua Wang, Dong Liang, Xiaojuan Li, and Leslie Ying.
• Department of Biomedical Engineering, Department of Electrical Engineering, State University of New York at Buffalo, Buffalo, USA.
• Magn Reson Med. 2016 Apr 1; 75 (4): 1617-29.

PurposeTo accelerate T1ρ quantification in cartilage imaging using combined compressed sensing with iterative locally adaptive support detection and JSENSE.MethodsTo reconstruct T1ρ images from accelerated acquisition at different time of spin-lock (TSLs), we propose an approach to combine an advanced compressed sensing (CS) based reconstruction technique, LAISD (locally adaptive iterative support detection), and an advanced parallel imaging technique, JSENSE. Specifically, the reconstruction process alternates iteratively among local support detection in the domain of principal component analysis, compressed sensing reconstruction of the image sequence, and sensitivity estimation with JSENSE. T1ρ quantification results from accelerated scans using the proposed method are evaluated using in vivo knee cartilage data from bilateral scans of three healthy volunteers.ResultsT1ρ maps obtained from accelerated scans (acceleration factors of 3 and 3.5) using the proposed method showed results comparable to conventional full scans. The T1ρ errors in all compartments are below 1%, which is well below the in vivo reproducibility of cartilage T1ρ reported from previous studies.ConclusionThe proposed method can significantly accelerate the acquisition process of T1ρ quantification on human cartilage imaging without sacrificing accuracy, which will greatly facilitate the clinical translation of quantitative cartilage MRI.© 2015 Wiley Periodicals, Inc.

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