• Riccardo Lattanzi, Christian Glaser, Artem V Mikheev, Catherine Petchprapa, David J Mossa, Soterios Gyftopoulos, Henry Rusinek, Michael Recht, and Daniel Kim.
• Department of Radiology, Center for Biomedical Imaging, New York University Langone Medical Center, New York, New York 10016, USA. riccardo.lattanzi@nyumc.org
• Magn Reson Med. 2011 Aug 1; 66 (2): 348-55.

AbstractEarly detection of cartilage degeneration in the hip may help prevent onset and progression of osteoarthritis in young patients with femoroacetabular impingement. Delayed gadolinium-enhanced MRI of cartilage is sensitive to cartilage glycosaminoglycan loss and could serve as a diagnostic tool for early cartilage degeneration. We propose a new high resolution 2D T1 mapping saturation-recovery pulse sequence with fast spin echo readout for delayed gadolinium-enhanced magnetic resonance imaging of cartilage of the hip at 3 T. The proposed sequence was validated in a phantom and in 10 hips, using radial imaging planes, against a rigorous multipoint saturation-recovery pulse sequence with fast spin echo readout. T1 measurements by the two pulse sequences were strongly correlated (R2>0.95) and in excellent agreement (mean difference=-8.7 ms; upper and lower 95% limits of agreement=64.5 and -81.9 ms, respectively). T1 measurements were insensitive to B1+ variation as large as 20%, making the proposed T1 mapping technique suitable for 3 T.Copyright © 2011 Wiley-Liss, Inc.

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