• Said Hilton, Gerhard Sattler, Anna-Karin Berg, Ulf Samuelson, and Cindy Wong.
• Medical Skin Center, Düsseldorf, Germany.
• Dermatol Surg. 2018 Feb 1; 44 (2): 261-269.

BackgroundHyaluronic acid (HA) fillers may differ in terms of gel characteristics and ease of use and it is of interest whether this might affect safety and duration of effect.ObjectiveTo compare the long-term safety and effect of 2 HA fillers produced by 2 different technologies for lip enhancement.Materials And MethodsSubjects with very thin to moderately thick lips were randomized and treated with HA-RK (N = 31) or HA-JV (N = 29) to improve lip fullness by ≥ 1 grade on a 5-point scale, using a maximum of 3 mL of product.ResultsA smaller volume of HA-RK compared with HA-JV was required to improve lip fullness by ≥ 1 grade (mean: 1.54 mL vs 1.94 mL, p < .001). Despite the smaller volume, lip fullness and global aesthetic improvement were comparably sustained in both groups. At 6 months, 60.0% versus 57.7% of subjects (HA-RK vs HA-JV) had improved lip fullness. At 12 months, 71.4% versus 76.0% had aesthetic improvement (blinded evaluations) and 85.7% versus 86.2% felt more attractive. Both products were well tolerated.ConclusionBoth products achieved durable improvement in lip fullness and aesthetic appearance. A significantly smaller amount of HA-RK was required compared with HA-JV to achieve optimal treatment effect.

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