• J Am Dent Assoc · Apr 1987

    Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants.

    • G A Ferretti, R C Ash, A T Brown, B M Largent, A Kaplan, and T T Lillich.
    • J Am Dent Assoc. 1987 Apr 1; 114 (4): 461-7.

    AbstractIntensive chemoradiotherapy damages the mucosal barrier of the mouth and throat and is often associated with severe oral inflammation and infection. This study examined the use of a 0.12% chlorhexidine gluconate mouthrinse for prophylaxis against oral complications in patients receiving bone marrow transplants. Use of chlorhexidine mouthrinse produced reductions in oral soft tissue disease and oral microbial burden, including a significant decrease in oral mucositis and Candida infections. The advantage for patients undergoing intensive antineoplastic therapy, and potentially for other immunocompromised patients susceptible to oral infections, was studied.

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