• Clinics in dermatology · Sep 2015

    Review Case Reports

    Systemic drug reactions with skin involvement: Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS.

    • Razvigor Darlenski, Jana Kazandjieva, and Nikolai Tsankov.
    • Department of Dermatology and Venereology, Tokuda Hospital-Sofia, 51 B Nikola Vaptsarov blvd, Sofia 1407, Bulgaria. Electronic address: darlenski@abv.bg.
    • Clin. Dermatol. 2015 Sep 1; 33 (5): 538-41.

    AbstractSkin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement. Copyright © 2015 Elsevier Inc. All rights reserved.

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