• Sebastian Domsch, Bettina Mürle, Sebastian Weingärtner, Jascha Zapp, Frederik Wenz, and Lothar R Schad.
• Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Germany.
• Magn Reson Med. 2018 Feb 1; 79 (2): 890-899.

PurposeThe oxygen extraction fraction (OEF) is an important biomarker for tissue-viability. MRI enables noninvasive estimation of the OEF based on the blood-oxygenation-level-dependent (BOLD) effect. Quantitative OEF-mapping is commonly applied using least-squares regression (LSR) to an analytical tissue model. However, the LSR method has not yet become clinically established due to the necessity for long acquisition times. Artificial neural networks (ANNs) recently have received increasing interest for robust curve-fitting and might pose an alternative to the conventional LSR method for reduced acquisition times. This study presents in vivo OEF mapping results using the conventional LSR and the proposed ANN method.MethodsIn vivo data of five healthy volunteers and one patient with a primary brain tumor were acquired at 3T using a gradient-echo sampled spin-echo (GESSE) sequence. The ANN was trained with simulated BOLD data.ResultsIn healthy subjects, the mean OEF was 36 ± 2% (LSR) and 40 ± 1% (ANN). The OEF variance within subjects was reduced from 8% to 6% using the ANN method. In the patient, both methods revealed a distinct OEF hotspot in the tumor area, whereas ANN showed less apparent artifacts in surrounding tissue.ConclusionIn clinical scan times, the ANN analysis enables OEF mapping with reduced variance, which could facilitate its integration into clinical protocols. Magn Reson Med 79:890-899, 2018. © 2017 International Society for Magnetic Resonance in Medicine.© 2017 International Society for Magnetic Resonance in Medicine.

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