• Jie Jiang, Yanming Hong, Tiantian Zhang, Zhihao Yang, Tengfei Lin, Zhuoru Liang, Peiyao Lu, Lishun Liu, Binyan Wang, Yongmei Xu, and Nan Luo.
• College of Pharmacy, Jinan University, Guangzhou, People's Republic of China.
• Qual Life Res. 2021 Jul 1; 30 (7): 2045-2060.

PurposeThe purpose of this study was to compare the measurement properties of two versions of EQ-5D (i.e.EQ-5D-3L and EQ-5D-5L) in hypertensive patients in rural China.MethodsA cross-sectional survey was carried out in hypertensive patients in rural China. We compared the ceiling effects, redistribution properties, informativity, known-groups validity, and relative efficiency of the 3L and 5L and examined their agreement.ResultsA total of 11,412 patients were enrolled in our study. The mean EQ-5D index score was 0.84 (SD 0.21) according to the 5L and 0.86 (SD 0.17) according to the 3L. A good agreement was observed between the 3L and 5L. The overall ceiling effect decreased from 46.4% (3L) to 29.4% (5L). The Shannon index, H' improved in all dimensions when used 5L. When used 3L, the median responses of all groups were consistent with 5L across the three dimensions of 'mobility', 'self-care', 'usual activities', while the median responses were inconsistent for the 'pain/discomfort' and 'anxiety/depression' dimensions. The 3L performed better in eight comorbidities in terms of F-statistics and six comorbidities in terms of the area under the receiver operating characteristic curves (AUROCs). The 5L performed better both in terms of the F-statistics and AUROCs in age, education level, anti-hypertensive medication use.ConclusionTaking all comparisons into account, we recommend the EQ-5D-5L for use in patients with hypertension in rural China.

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