• Laura Macías-García, Haydee De la Hoz-Herazo, Antonio Robles-Frías, María J Pareja-Megía, Juan López-Garrido, and José I López.
• Unidad de gestión clínica de Oncohematología y Anatomía Patológica, Hospital Universitario de Valme, Carretera de Cádiz s/n, 41014, Sevilla, Spain. laura.macias.garcia@gmail.com
• Diagn Pathol. 2012 Oct 30; 7: 150.

BackgroundGastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies in adults (<2%). GISTs can be located at any level of the gastrointestinal tract; the stomach is the most common location (60-70%), in contrast to the rectum, which is most rare (4%). When a GIST invades into the adjacent prostate tissue, it can simulate prostate cancer. In this study, we report on a case comprising the unexpected collision between a rectal GIST tumour and a prostatic adenocarcinoma.FindingsWe describe the complexity of the clinical, endoscopic and radiological diagnosis, of the differential diagnosis based on tumour biopsy, and of the role of neoadjuvant therapy using imatinib prior to surgical treatment.ConclusionsAlthough isolated cases of coexisting GISTs and prostatic adenocarcinomas have previously been described, this is the first reported case in the medical literature of a collision tumour involving a rectal GIST and prostatic adenocarcinoma components.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1238437468776331.

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