• Trends in immunology · Oct 2018

    Hiding in Plain Sight: Soluble Immunomodulatory Receptors.

    • Lekh N Dahal, Herbert Schwarz, and Frank J Ward.
    • Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: L.N.Dahal@soton.ac.uk.
    • Trends Immunol. 2018 Oct 1; 39 (10): 771-774.

    AbstractAlternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.Copyright © 2018 Elsevier Ltd. All rights reserved.

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