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Gan To Kagaku Ryoho · Nov 2009
[Results of neo-adjuvant chemotherapy by FOLFOX and FOLFIRI for colorectal liver metastasis].
- Ryosuke Amano, Nobuya Yamada, Eiji Noda, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Toru Inoue, Masakazu Yashiro, Kiyoshi Maeda, Naoyoshi Onoda, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Tetsuro Ishikawa, and Kosei Hirakawa.
- Department of Surgical Oncology, Osaka City University Graduate School of Medicine.
- Gan To Kagaku Ryoho. 2009 Nov 1; 36 (12): 2003-5.
AbstractWe analyzed a treatment outcome and the effect of FOLFOX and FOLFIRI neo-adjuvant chemotherapy (NAC) for patient with liver metastasis of colorectal cancer. Eleven patients undergoing hepatectomy after NAC were investigated. FOLFOX was performed for 8 patients, and FOLFIRI was for 3 patients. The response rate was 45.5% (PR 5, SD 6), and the reduction rate was 37.7%. The average ICG R15 value before hepatectomy was 13.7%. A complication during and after operations was not recognized. The average observation period was 19.8 months (8-45 months). Now, 9 patients are alive with no recurrence. NAC by FOLFOX for liver metastasis of colorectal cancer showed a high reduction rate, and there was a little influence to hepatectomy indicating that FOLFOX could be an effective therapy.
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