• C J Fleming, A M Bryden, A Evans, R S Dawe, and S H Ibbotson.
• Departments of Dermatology and Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. colin.j.fleming@tuht.scot.nhs.uk
• Br. J. Dermatol. 2004 Aug 1; 151 (2): 485-8.

BackgroundLentigo maligna (LM) is an in situ form of malignant melanoma, and surgical excision is often unsatisfactory. Imiquimod cream is an immune response modifier and induces a predominantly T-helper 1 type response.ObjectivesAssessment of histological and clinical response of surgically resectable LM after treatment with 5% imiquimod cream.MethodsSix patients with LM were treated with 5% imiquimod cream daily for 6 weeks. The whole site of the original lesion was then excised. Clinical and histological and appearances were measured using clinical response and histological grading scores.ResultsComplete or almost complete clearance of pigmentation with minimal residual histological evidence of LM was observed in four patients, one patient showed no clinical or histological improvement, and the remaining patient had almost no residual pigmentation clinically after treatment yet histopathological changes remained as severe as before treatment.ConclusionsTopical imiquimod cream merits further investigation as a new therapy for LM.

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