• J Minim Invasive Gynecol · Feb 2015

    Observational Study

    Effect of undiagnosed deep adenomyosis after failed NovaSure endometrial ablation.

    • Bianca B Mengerink, van der WurffAnneke A MAADepartment of Pathology, St Elisabeth Hospital, Tilburg, The Netherlands., Johanne F ter Haar, Ilse A van Rooij, and Johanna M A Pijnenborg.
    • Department of Obstetrics and Gynecology, Rijnstate Hospital, Arnhem, The Netherlands; Department of Obstetrics and Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: BiancaMengerink@radboudumc.nl.
    • J Minim Invasive Gynecol. 2015 Feb 1; 22 (2): 239-44.

    Study ObjectiveTo determine the prevalence of adenomyosis and deep adenomyosis after NovaSure (Hologic Inc., Newark, DE) endometrial ablation in hysterectomy specimens after NovaSure endometrial ablation failure.DesignProspective observational study (Canadian Task Force classification II-2).SettingThe TweeSteden Hospital, a teaching hospital in the south of the Netherlands.PatientsAll women who underwent hysterectomy for menorrhagia and/or dysmenorrhea after failure of NovaSure endometrial ablation between November 2007 and January 2011.InterventionsAll patients who underwent hysterectomy between January 2005 and April 2009 for the same indication but did not undergo prior endometrial ablation from choice or the lack of availability of the endometrial ablation procedure.Measurements And Main ResultsOf 213 patients who underwent NovaSure therapy, 22 (10.3%) underwent a hysterectomy because NovaSure failed. Of these, 10 (45.5%) exhibited adenomyosis in their hysterectomy specimens. The control group patients had a similar adenomyosis prevalence (74/173, 42.8%). However, the NovaSure failure group had a significantly higher prevalence of deep adenomyosis (>2.5 mm endometrial penetration) (9/22, 40.9%) than the control group (37/173, 21.4%, p < .05).ConclusionDeep adenomyosis after failed NovaSure endometrial ablation was present in a significant number of patients. It is not clear whether adenomyosis is induced by endometrial ablation or whether it causes endometrial ablation failure.Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.

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