• Rheum. Dis. Clin. North Am. · May 2009

    Review

    Complex adaptive systems allostasis in fibromyalgia.

    • Manuel Martinez-Lavin and Angelica Vargas.
    • Rheumatology Department, National Cardiology Institute, Mexico City, Mexico. mmlavin@terra.com.mx
    • Rheum. Dis. Clin. North Am. 2009 May 1; 35 (2): 285-98.

    AbstractFibromyalgia (FM) can be conceptualized as a failed attempt of our main complex adaptive system (the autonomic nervous system) to adjust to a hostile environment. FM cannot be fully understood through the prevailing linear-reductionist medical model. Conversely, FM can be explained using the new complexity theory paradigms. Relentless sympathetic hyperactivity in FM may be a sign of allostasis. Similarly sympathetic hyporeactivity to stress may indicate allostatic load. Dorsal root ganglia have been suggested as important sympathetic-nociceptive short-circuit sites. Autonomic dysfunction also explains non-pain-related FM features. Preliminary genetic evidence supports FM's dysautonomic nature. A scientific holistic therapy is proposed to harmonize rigid complex systems and, in doing so, to help to improve FM symptoms.

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