• Pharmacol. Biochem. Behav. · Jun 2014

    Review

    Antidepressant-induced sexual dysfunction in men.

    • Robert Taylor Segraves and Richard Balon.
    • Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: Rsegraves3@hotmail.com.
    • Pharmacol. Biochem. Behav. 2014 Jun 1; 121: 132-7.

    AbstractMost of the available antidepressant medications, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and dual noradrenergic/serotonergic reuptake inhibitors have been reported to be associated with sexual dysfunction in both sexes. This manuscript reviews evidence concerning the relative incidence of treatment emergent sexual dysfunction in men being treated with antidepressant drugs. Both double-blind controlled trials and large clinical series report a high incidence of sexual dysfunction, especially ejaculatory delay, with serotonergic drugs. The incidence of sexual dysfunction in men appears to be much lower with drugs whose primary mechanism of action involves adrenergic or dopaminergic systems. Copyright © 2013 Elsevier Inc. All rights reserved.

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